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IGF-1 increases plasma renin activity and suppresses atrial natriuretic factor, the hormone responsible for sodium excretion

& Yu, Y.-H

The most significant clinical data for retatrutide to date comes from a Phase 2 randomised controlled trial published in The New England Journal of Medicine in 2023 (Jastreboff et al., NEJM 2023)

In summary, our data implicate a novel mechanism protecting against liver steatosis via an oxidative stress adaptive response that activates the AMPK pathway

Contact your GP if fasting glucose consistently exceeds 7 mmol/L or if you experience symptoms of hyperglycaemia after missing doses

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