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Small-Molecule GLP-1 Drugs Target the Brains Emotion and Reward Centers Peptide GLP-1 agonists are difficult to manufacture, store, and administerthey must be injected

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Some rodent studies found that exenatide reduced oxycodone self-administration and heroin-seeking behaviors, while others reported minimal effects on morphine-related behaviors

[DOI] [PMC free article] [PubMed] [Google Scholar] 70.Wang X., Zhang Q., Bao R., Zhang N., Wang Y., Polo-Parada L., Tarim A., Alemifar A., Han X., Wilkins H.M., et al

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