Numerous GLP-1 receptor-targeting drugs have been investigated in clinical studies for various indications, including type 2 diabetes and obesity (accounts for 70% of the total studies), non-alcoholic steatohepatitis, Alzheimer's disease, and Parkinson's disease
C.EssenwangerJ.StolzJ.et al (2017)
Most practitioners prefer the no DAC version because its more physiologic and allows easier dose adjustment
By carrying antioxidants, immunomodulatory drugs, or targeting moieties, these NPs shift microglia away from neurotoxic phenotypes and bolster clearance of pathogenic proteins
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Associated symptoms included hypotonia, muscle weakness and failure to thrive