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Media Attributions Figure 11.1.1 Steven Earle, CC BY SA 4.0, after Water Cycle by Ingwik, CC BY SA 3.0, via Wikimedia Commons, Figure 11.1.2 Steven Earle, CC BY 4.0 Figure 11.1.3 Modified by Steven Earle, from Mackenzie River with Heavy Sediment Load by Pierre Markuse, 2018, CC BY 2.0 via Flickr,
The standard 4-6 weeks on, 2-4 weeks off pattern provides a structured approach even without specific data guiding these intervals
The structural changes lower its affinity for IGF binding proteins and stretch its half-life to roughly 20-30 hours
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