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Mechanistically, IgG-autoantibodies induced an enhanced nuclear translocation of the transcription factor cAMP response element modulator (CREM) and its binding to the GPX4 promoter

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Gogos and Shapiro, In the structures of human and yeast GS, two alanine residues form van der Waals contacts with the glycine moiety of glutathione (Polekhina et al., 1999