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Recent findings indicate that rifaximin significantly enhances objective sleep architecture, notably increasing REM sleep, after a 28-day treatment course as evidenced by 24-h polysomnography, although it did not alter subjective perceptions of sleep quality and sleepiness (31, 33)

a pooled analysis of SURPASS trials showed that nausea severity correlated with dose escalation speed rather than with occasional interval widening [6]

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Furthermore, estrogens increase the mitotic activity of lactotrophs, increasing cell numbers