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Cardiovascular tissue displays robust circadian oscillations in cells including vascular smooth muscle, fibroblasts, cardiomyocytes, and cardiac progenitor-like cells, all of which regulate physiological functions including endothelial function, blood pressure, and heart rate (Paschos and FitzGerald, 2010)

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They noted that it may be an effective option to treat mild to moderate ED

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As such, the ascorbate both suppresses free radicals and stimulates the oxidant system on the cells while acting on antioxidant enzymes as a ROS eliminator [51]