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Gallbladder disease including gallstones may occur, particularly with rapid weight loss

The gradual dose escalation protocols used with these medicationsdesigned to minimize gastrointestinal adverse effectsmean that maximum efficacy may not be apparent until patients reach therapeutic doses after several months

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Szeliga, J., Nafta (Katowice) 1978, 12, 413-7

Some people may experience side effects after taking metformin, with the main symptoms being gastrointestinal distress and, in rare cases, lactic acidosis (Sanchez-Rangel and Inzucchi, 2017)

The deglutamylation activities of AsGGT1, AsGGT2, and AsGGT3 toward -glutamyl- S -allyl-L-cysteine were decreased in the absence of glycylglycine ( Figure 5 ), indicating that these garlic GGTs can catalyze transpeptidation more effectively than hydrolysis