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GLP-1 receptor agonists (semaglutide, liraglutide, dulaglutide) and GIP/GLP-1 dual agonists (tirzepatide) carry the clinical evidence: STEP (semaglutide, NEJM 2021), SURMOUNT (tirzepatide, NEJM 2022), and SURMOUNT-OSA (tirzepatide for obstructive sleep apnea, NEJM 2024)

For many people, these symptoms are mild to moderate and improve over time, particularly once the body adjusts to the medication

Dose ceilings exist for safety and tolerability reasons

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Route of administration varies across studiesintraperitoneal injection in rodent models, subcutaneous in larger animals, and oral in gastric protection studies