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Unlike setmelanotide, which can activate melanocortin receptors MC3R and MC1R in addition to MC4R 36 , RM-718 by design, avoids stimulating MC1R 40 and thereby avoids the common hyperpigmentation adverse event 41 that can arise when MC1R is stimulated 42

DO NOT USE if you are pregnant or nursing, prone to dehydration, or exposed to excessive heat

DOI: 10.1213/ane.0000000000007764

Because hemophilia is a rare condition, people with hemophilia may not be well represented in studies that assess the safety of these drugs

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Personalized Protocol Dosing, administration route (subcutaneous injection or oral, depending on your goals), frequency, and duration are tailored to your specific situation not copied from a Reddit thread