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Have a personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2, which rules out GLP-1 therapy entirely, regardless of provider

Sermorelin's effects are modulated by natural negative feedback mechanisms, primarily somatostatin, reducing the risk of excessive HGH production

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Research published in obesity medicine journals indicates that GLP-1 medications primarily act on appetite centers in the hypothalamus and reward pathways, not on prefrontal cortex function

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