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10.1038/cddis.2015.348 87 WangC.YangZ.XuE.ShenX.WangX.LiZ.et al (2021a)

Structures of active receptors reveal peptide agonists engage deep within the receptor core, leading to an outward movement of extracellular loop 3 and the tops of transmembrane helices 6 and 7, an inward movement of transmembrane helix 1, reorganization of extracellular loop 2 and outward movement of the intracellular side of transmembrane helix 6, resulting in G-protein interaction and activation 2,3,4,5,6

A later variant melanotan II, shorter, more potent, and with a particular affinity for receptors governing sexual arousal and appetite turned out to be something the researchers hadnt planned for at all

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