284 A similar phenomenon has been observed in Gln-dependent clear cell renal carcinoma (RCC), which competitively depletes environmental Gln, causing local Gln depletion and IL-23 release from tumor-infiltrating macrophages, which further activates Treg function to suppress tumor immunity
217, Aug
Once weight has stabilised typically after six to twelve months on a maintenance dose and nutritional markers (protein, iron, vitamin D) have been corrected, a transplant becomes a realistic option
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