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Melanotan II was originally developed as a tanning agent based on an earlier drug called afamelanotide (previously "Melanotan I") [1] which is now approved by the FDA for the treatment of a particular rare genetic form of sun sensitivity

These studies help researchers pinpoint a safe dose

Compared to monotherapy, the combination group had higher rates of overweight/obesity, type 2 diabetes, hypertension, and hyperlipidemia, but lower rates of ischemic heart disease, heart failure, and atrial fibrillation

It also inhibited tumor development in other parts of the intestine (6)

doi: 10.1530/eje.0.1500235

The results were varied on whether GLP-1 agonists have the potential to preserve BMD and BMC