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Sodium-glucose co-transporters are responsible for 97% of glucose reabsorption6 and their inhibition lowers blood glucose by increasing renal glucose excretion.4 , 5 Using SGLT-2 inhibitors increases the risk of DKA6 , 7 by decreasing daily carbohydrate availability by 20%45%,9 lowering endogenous insulin production and stimulating lipolysis that leads to ketogenesis.6 Patients who also receive insulin may decrease insulin doses in response to lower blood glucose patterns, leading to insulin deficiency

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It would be interesting to investigate a more extensive study population to assess the potential beneficial effects of CRWP in female children with ASD, as the manifestations of ASD can differ between males and females ( Conclusion In conclusion, this study demonstrated that nutritional intervention with CRWP effectively improved glutathione levels in children with ASD, ameliorated some behavioral domains impacted in ASD and was well-tolerated

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