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The activation of TLRs causes conformational changes in the TIR domain and allows the recruitment of cytoplasmic adapter proteins such as TIR domain-containing adaptor protein (TIRAP, MAL), myeloid differentiation primary response protein MyD88 (MyD88), TIR domain-containing adapter-inducing interferon- (TRIF, TICAM1) and TRAM that anchor the TIR domain

10.1016/0005-2760(82)90150-3 150 WangM.KaufmanR

10.1016/j.jpsychires.2022.01.061 J Psychiatr Res

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MOTS-c half-life is approximately 2 to 4 hours, but the downstream cellular effects (mitochondrial biogenesis, gene expression changes) persist well beyond serum clearance

Key takeaways: Methylene blue is a salt and dye with antioxidant, anti-inflammatory, antidepressant and analgesic properties