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In the SURMOUNT-1 trial, tirzepatide produced average weight reductions of 15.0%, 19.5%, and 20.9% at studied doses compared with 3.1% with placebo over 72 weeks

These findings suggest that liraglutide specifically reduces bone resorption without influencing bone formation

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This hormonal response helps slow gastric emptying, promote fullness, and reduce overeating after meals

While this number might seem high, its important to keep in mind that I was eating significantly fewer calories which led to an immediate decrease in weight through sheer reduction in food intake

[1] [2] Fasting plasma concentrations of biologically active GLP-1 range between 0 and 15 pmol/L in humans and are increased 2- to 3-fold upon food consumption depending on meal size and nutrient composition