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The Cre-carrying IGF-1R heterozygous mice were backcrossed with homozygous IGF-1R floxed mice

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Although little evidence supports the routine use of supplemental thiamin in CHF patients, trials specifically in CHF patients with marginal thiamin status have not been done, and some suggest that it may be prudent to screen patients on long-term diuretic therapy for thiamin deficiency and treat accordingly (84)

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PH: Is recipient of consultancy/llecture fees or unrestricted research grants from Sanofi/Regeneron, Novartis, GSK, Medtronic and Viatris