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In an in vitro co-culture model, astrocyte-derived transforming growth factor-1 upregulated the expression of the tight junction protein zonula occludens-1 in brain microvascular endothelial cells and reinforced endothelial barrier function through non-canonical hedgehog signaling [90]

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The Okinawan Helios Distillery came to greater attention (and reknown) of the western rum scene in 2019, when they presented a white rum and a 5 Year Old that were impressive right out of the gate

10.1046/j.1528-1157.2001.18001.x Epilepsia