Benefits for Heart, Kidney and Brain Health GLP-1 agonists and SGLT2 inhibitors, both used in managing Type 2 diabetes, show distinct impacts on the heart, kidneys, and brain: Cardiovascular and Renal Effects: SGLT2 inhibitors, such as empagliflozin, significantly reduce the risk of heart failure and cardiovascular mortality in Type 2 diabetes patients
Cell functions such as neurotransmission, release of hormones and inflammatory factors (cytokines, extracellular vesicles)
Dawed AY, Mari A, Brown A, McDonald TJ, Li L, Wang S, Hong MG, Sharma S, Robertson NR, Mahajan A et al (2023) Pharmacogenomics of GLP-1 receptor agonists: a genome-wide analysis of observational data and large randomised controlled trials
Kim PK, Hailey DW, Mullen RT, Lippincott-Schwartz J
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