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Some improvements correlate with early weight loss, while direct vascular effects from GLP-1 receptor activation may contribute independently

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Effects of tirzepatide versus insulin glargine on cystatin C-based kidney function: a SURPASS-4 post hoc analysis

Losing 10% of body weight may help reduce inflammation and even fibrosis in the liver

Adverse events: headache, dry mouth, insomnia Phentermine-related adverse events primarily include mild to moderate symptoms affecting patient comfort but typically not requiring discontinuation