what is gip and glp-1 GLP‐1, the two incretin hormones: Similarities and differences GIP (Gastric Inhibitory Polypeptide) Assay

63 , R93R102 (2019)

The potency of DO3A-Tuna-2 at human recombinant GCGR (EC 50 0.4 pM) is comparable to that of native glucagon (EC 50 0.5 pM)

For Medicare beneficiaries, the situation has historically been the most difficult

The STEP 1 trial for semaglutide 2.4mg demonstrated a mean body weight reduction of approximately 14.9% over 68 weeks in adults with obesity. The SURMOUNT-1 trial for tirzepatide showed reductions of up to 22.5% at the highest dose. These are outcomes that approach the efficacy of bariatric surgery in some patient cohorts

Mansur SA, Mieczkowska A, Flatt PR, Chappard D, Irwin N, Mabilleau G

doi:10.1016/B978-0-12-800101-1.00002-8 30