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CagriSema (cagrilintide + semaglutide) is the closest human analog with Phase 3 data

Nausea affects approximately 15-20% of patients, with vomiting (5-9%), diarrhea (8%) and abdominal pain (6-7%) also common

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NICE Clinical Knowledge Summaries advise oral cyanocobalamin for dietary deficiency, while intramuscular hydroxocobalamin is recommended for pernicious anaemia or malabsorption syndromes

Some people transitioning from high-dose tirzepatide or semaglutide report a temporary period where appetite suppression feels weaker before retatrutide glucagon receptor effects begin contributing meaningfully

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