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10.1186/s12967-022-03272-3 132 OzakiT.YoshinoY.TachibanaA.ShimizuH.MoriT.NakayamaT.et al
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Importance of Timely Diagnosis and Treatment Hormone deficiencies worsen with age if left untreated: Testosterone declines 1-2% per year after age 30 Growth hormone secretion falls 14-15% per decade 90% of adults over 35 show some thyroid dysfunction This leads to reduced vitality and increased disease risk over time
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[1] [4] For most individuals, nausea tends to be most pronounced during the first few weeks of therapy , particularly after starting treatment or following a dose increase
Regarding CV safety, semaglutide 14 mg was non-inferior to placebo based on time from randomization to first EAC-confirmed MACE indicating no increase in risk in the occurrence of MACE with semaglutide compared to placebo
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