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Subjective evaluations Skin whitening and smoothening at the test site and improvement in fine lines were evaluated subjectively by the investigator and by the subjects in accordance with the following scoring pattern: 3= marked deterioration 2= moderate, visibly uneven deterioration 1= slight deterioration 0= no perceptible change or improvement 1= slight change or improvement 2= moderate change or improvement (whitening

Some disorders of organic acid metabolism can be treated by limiting the intake of precursors

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Nature 490 , 412416 (2012)