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Chemistry of Materials, 17(21), 5255-5262

Excess nicotinamide is eliminated partly through a methylation pathway, meaning it consumes methyl donors in the process of excretion

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While AOD9604 has not achieved the commercial success initially envisioned, it has contributed valuable insights into the dissociable functions of different regions of the growth hormone molecule and has validated the concept that targeted metabolic effects can be achieved without unwanted growth hormone receptor activation

GI events were the most common adverse effects, vast majority mild to moderate