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ASK1, also known as MAP3K5, activates the downstream p38-JNK1/2 signalling pathway, thereby promoting inhibition of lipid and glucose metabolism 34,35,36 and driving a strong inflammatory response 37

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Doing a little more math, we can estimate that in 2023, Kaiser has roughly 6 million members with obesity (0.48 times 12.6 million members = 6,048,000)