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Xu G, Kaneto H, Laybutt DR et al (2007) Downregulation of GLP-1 and GIP receptor expression by hyperglycemia: possible contribution to impaired incretin effects in diabetes

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However, the FDA has issued a strong warning: certain bulk drug substances used in compounding may carry serious safety risks and, in some cases, may violate federal law

Therapeutic peptides work on that same principle: you're not introducing a foreign substance (when manufactured safely), you're speaking the body's own language, just at a higher volume and for longer than it would naturally sustain