Monitoring approach: Establish clear metrics (visual field, OCT, visual acuity), measure every 3-6 months, continue peptides if stable or improving, consider break if stable 12+ months on treatment, resume immediately if decline detected during break, accept ongoing use if clearly beneficial and well-tolerated
How this process was operationalised in the two trials is described in Table 2
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BrzezinskiAVangelMGWurtmanRJNorrieGZhdanovaIBen-ShushanAet alEffects of exogenous melatonin on sleep: a meta-analysis
The amino acid sequence is amended to switch a lysine for an arginine, leaving only one lysine in the sequence, which is used to introduce the fatty acid side chain
