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After reading about the triple agonist mechanism and seeing the trial data, I decided to give it a try

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doi: 10.1038/s41598-017-18756-2 91 ZuoKLiJLiKHuCGaoYChenMet al

The authors thankfully acknowledge the high-performance computational facility in the School of Computing at SASTRA Deemed University for providing computational resources to complete the simulation studies