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Durante esses estudos, Pickart observou um fenmeno intrigante: quando clulas hepticas envelhecidas eram expostas ao plasma de indivduos jovens, recuperavam caractersticas metablicas semelhantes s de clulas mais jovens

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Owing to its ability to accommodate multiple substrates, the TCA cycle plays a central role in cellular metabolism

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(2008), measures of enzyme activity were used (creatine kinase, lactate dehydrogenase, aspartate aminotransferase, alanine aminotransferase), allowing a gauge of trauma response (proteolysis) and therefore the ability to further understand the mechanisms of action

To help measure patient-perceived benefits of treatment, PROs are increasingly recognised as important [29, 30] and are being integrated into the clinical trial programmes of antihyperglycaemic treatments [20, 28, 36, 37]