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From a canonical point of view, ATP Citrate Lyase (ACL) produces acetyl-CoA from mitochondrion-derived citrate

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doi: 10.1016/S0006-8993(98)00936-6 153 FungfuangWNakadaTNakaoNTeradaMYokosukaMGizurarsonSet al

However, rare kidney adverse events have been reported: orlistat has been associated with hyperoxaluria and oxalate nephropathy, and GLP-1 receptor agonists have been linked to AKI secondary to dehydration