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Tirzepatide has no known direct drug interactions with SSRIs, SNRIs, or bupropion

Sexual activity may be a strain on your heart, especially if you have heart disease

But like any medication, GLP-1s carry a few risks alongside their benefits

Choi says it may be easier to become frustrated or experience side effects that lead to discontinuing the medicine before understanding if it will truly work for you

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While GLP-1 based therapies are highly effective at managing weight reduction, gastrointestinal (GI) side effects, including nausea (2544 %), diarrhea (1932 %), vomiting (825 %), constipation (1223 %) and abdominal pain (510 %), were common in pivotal Phase 3 studies, although generally transient in nature [[40], [41], [42],46]