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Animal LD50 studies showed toxic levels around 320 mg/kg body weight, translating to approximately 22,400 mg for a 70 kg human

Long-term safety data are limited

The invisible degradation problem The frustrating reality is that early-stage degradation produces no visible changes

In addition, hydroxocobalamin may be used as part of the treatment for cyanide poisoning (as an antidote), although in such emergency cases very high doses are administered under hospital care