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Endocrinology 140 , 16871694 (1999)

Individual genetic variation GLP-1 receptor density, GIP receptor sensitivity, and glucagon receptor expression vary between individuals

Dosages may be adjusted over time to improve tolerability and effectiveness

The right and left vagal nerves enter the abdomen as two trunks that divide into distinct primary branches at the subdiaphragmatic esophageal level 39

For example, a medication might strongly activate brain GLP-1 receptors for appetite suppression while only partially activating gut receptors that contribute to nausea