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Weeks 13+: 10-12 mg per week (maintenance) The highest clinical doses
Importantly, degraded peptide solutions may appear visually unchanged the solution may still look clear and colourless even if the active molecule has been compromised
This observation sparked interest in developing medications that could boost incretin activity, potentially treating both diabetes and obesity
Research has shown that GLP-1, along with other gut-brain peptides like ghrelin, leptin, and galanin, acts on the mesolimbic dopamine system of the brain and influences the activation of this system by alcohol and other addictive drugs
This need is increasing with the trend of switching from intravenous to subcutaneous delivery. To address the increased trend toward self-administration of large-volume biologics, Nemeras key focus this year has been on the development of an on-body injector platform for complex, large-volume drugs (20mL) delivery, such as monoclonal antibodies with an adjustable flow rate to fit both patients and drugs administration profiles
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