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Targeted clearance of mitochondria by an autophagy-tethering compound (ATTEC) and its potential therapeutic effects

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Sun (2021) a Chinese group working with APP/PS1 amyloid-pathology mice showed restoration of spatial learning with oral dosing (1.442.88 mg/kg, 3 months): neuron and synaptophysin counts rose, astrocyte and microglial activation fell, IL-1 and TNF- dropped and anti-inflammatory IL-10 increased

Horne BD, Muhlestein JB, Lappe DL, May HT, Carlquist JF, Galenko O et al (2013) Randomized cross-over trial of short-term water-only fasting

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