Injection site rotation is important for all injectable GLP-1 medications
Table of Contents Mechanism of action of GLP-1 The emerging clinical research and drug marketing Wegovy and Ozempic, side-by-side Side effects and adverse events Current anesthesia care guidance on patient care Summary of where we are Mechanism of action of GLP-1 GLP-1 is a hormone inactivated by the enzyme DPP-4
Amplifies beta-cell insulin secretion through pathways distinct from GLP-1R, modulates adipose tissue lipid handling, and appears to reduce the GI adverse-event burden associated with isolated GLP-1R agonism
therefore, ages with higher cardiovascular mortality as a share of overall mortality are expected to see greater mortality reductions
Eight major RCTs of GLP-1RAs have investigated the cardiovascular outcomes, including the ELIXA trial of lixisenatide (250), the EXSCEL trial of exenatide ER (251), the LEARDER trial of liraglutide (252), the SUSTAIN-6 trial of subcutaneous semaglutide (253), the HARMONY trial of albiglutide (228), the REWIND trial of dulaglutide (254), the PIONEER trial of oral semaglutide (255), and the SELECT trial of subcutaneous semaglutide (199)
Get a comprehensive hormone panel If you have not had your sex hormones checked since starting GLP-1 therapy, request a full panel including total and free testosterone, estradiol, SHBG, LH, FSH, and thyroid function
