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The multi-center, randomized, double-blind, placebo-controlled trial involved a total of 232 diabetic patients (aged 18-70 years) diagnosed with DPN and presenting with abnormal nerve conduction velocity (NCV) in at least one nerve of the extremities

But until then, we need a balanced perspective

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For instance, SAP-induced MMP-9 activation accelerates glycocalyx degradation, thereby directly linking pancreatic inflammation to systemic microcirculatory collapse [18]