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Application and Usage: HOCl-based formulations, as seen in these studies and reviewed by Natarelli et al
In excess, these highly-reactive species cause oxidative stress which is responsible for significant cell damage
Therefore, we conclude that, in the absence of LDHB, RSL3 treatment indeed leads to increased mitochondrial lipid peroxidation levels, which agrees with a function of GPX4 in the mitochondria, as reviewed before 42
