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Samples were then evaporated to dryness in Speed vac and resuspended in 500 l Velos buffer A (95% H 2 O, 5% CH 3 CN, 0.1% FA) with additional 20 l of 20% FA to ensure the samples were acidic

As a Nrf2 activator, urolithin A not only protects kidney against oxidative stress via promoting Nrf2 translocating into nucleus (Zhang et al., 2022c), but also ameliorates hyperuricemic nephropathy via enhancing PINK1-associated mitophagy in renal TECs (Zhang et al., 2022a)

Patients often want to know exactly when they will notice results, but Sermorelin does not follow one universal timeline