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Tirzepatide functions as both a glucose-dependent insulinotropic polypeptide (GIP) receptor and glucagon-like peptide-1 (GLP-1) receptor agonist

A meta-analysis of GLP-1 receptor agonist trials found no statistically elevated pancreatitis risk when compared to placebo

After inducing ischemic AKI in 810-week-old, male C57BL/6 mice, mass spectrometry metabolomics revealed that the liver had the most distinct phenotype 24 h after AKI versus 4 h and 7 days

Obesity rate: 40% (2022) to 37% (2025)