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Taken together, the current available data suggest that GH and/or IGF-1 regulate acid-base hemostasis by stimulation of ammonia production in the proximal renal tubule and/or by a Na-dependent mechanism in the collecting duct, resulting in enhanced proton secretion

PMID 14672298

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There is a significant body of research, mostly from the 2000s, on the homocysteine-lowering benefits of B12 in patients with end-stage renal disease and who are on haemodialysis (HD), 80100% of whom have elevated homocysteine levels

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[DOI] [Google Scholar] 36.Grishin D.V., Zhdanov D.D., Pokrovskaya M.V., Sokolov N.N