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Acute peripheral administration of synthetic human GLP-1 (7-36 amide) decreases circulating IL-6 in obese patients with type 2 diabetes mellitus: a potential role for GLP-1 in modulation of the diabetic pro-inflammatory state

Elkind-Hirsch et al., in a 24-weeks intervention, indicated that exenatide monotherapy or its combination with MET was overall superior to MET monotherapy in terms of weight, abdominal fat, and insulin sensitivity

Answer: There is no strict upper limit, but most protocols build in breaks after 12 to 16 weeks of continuous use to limit tolerance

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