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Hematology Oncology 15 (1), 174

[73] As noted above, the completely synthetic laboratory synthesis of B 12 was achieved by Robert Burns Woodward and Albert Eschenmoser in 1972, though this process has no commercial potential, requiring more than 70 steps and having a yield well below 0.01%

In the before photo, you see the challenge

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In the European Union , it's regulated under each member state's pharmaceutical laws but is generally not approved for human use