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These benefits were seen despite comparable weight loss and glycemic control, indicating that the effect on cognitive function is independent of the effect on weight and hyperglycemia [59]
However, in chronic critical illness, glutathione synthesis may be impaired by cysteine depletion, protein-energy malnutrition, hyperglycemia, pharmacological doses of glucocorticoids, and decreased anterior pituitary hormone secretion
Oral supplementation and a healthy diet are usually sufficient
Still, case reports are published showing interactions between ascorbic acid and warfarin (with INR climbing from 1.1 to 15.4 within 2 days after the discontinuation of vitamin C) [299]
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