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Important observations All five clinical trials that were included in the analysis reported GLP-1 receptor agonist-mediated reduction in substance use disorder, with two trials respectively reporting a significant therapeutic impact of GLP-1 receptor agonist in reducing alcohol use disorder and nicotine use disorder

Variants in SLC22A5 were further detected by next-generation sequencing in individuals with abnormal free carnitine levels (C0)

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In addition, shifting away from mandatory surgical confirmation toward a clinically driven diagnostic model supported by imaging can accelerate diagnosis and initiation of treatment