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Based on current evidence, the most accurate answer is: it probably doesnt matter as much as you think

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This includes HPLC or equivalent methods for L-carnitine assay, heavy metals testing (lead, arsenic, cadmium, mercury), microbial testing (total plate count, yeast/mold, pathogens), and residual solvent testing

WO 02/069905 and United States Patent Application US 2003/0069169 disclose a "method of regulating