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Recent findings also revealed concerns with the loss of skeletal muscle mass when taking GLP-1RAs with some studies reporting up to 50% of weight loss being due to decreases in muscle mass

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Common gastrointestinal side effects include: Nausea (reported in up to 20% of patients in clinical trials) [20] Vomiting and diarrhoea Constipation Abdominal pain and bloating Reduced appetite These symptoms are typically mild to moderate in severity and often improve over time as the body adjusts to the medication

8) Obesity Higher activity of the FMO3 enzyme, responsible for producing TMAO, was associated with higher body mass index (BMI), waist-to-hip ratio, and body fat, but lower insulin sensitivity, in 770 men [37]

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