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### What the Clinical Data Shows Analysis of STEP trial body composition data published in *Diabetes, Obesity and Metabolism* (2023) revealed: - Approximately **6075% of total weight lost on semaglutide was fat mass** - The remaining 2540% included water, glycogen, and some lean tissue - Lean mass loss was proportional to what is expected with any significant weight reduction ### How Bodybuilders Can Optimize Muscle Preservation on GLP-1 Peptides The key insight for the bodybuilding community is that lean mass loss on GLP-1 peptides is **highly modifiable** through training and nutrition
Under step therapy requirements, patients may be asked to try lower-cost interventions before a GLP-1 medication is approved
